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Global surveillance of animal influenza for the control of future pandemics

Identifieur interne : 001835 ( Main/Exploration ); précédent : 001834; suivant : 001836

Global surveillance of animal influenza for the control of future pandemics

Auteurs : H. Kida [Japon] ; K. Okazaki [Japon] ; A. Takada [Japon] ; H. Ozaki [Japon] ; M. Tashiro [Japon] ; D. K Lvov [Russie] ; K. F Shortridge [République populaire de Chine] ; R. G Webster [États-Unis]

Source :

RBID : ISTEX:12AED5A54B9DFC625391BD0364840A0F745CA293

English descriptors

Abstract

Abstract: Influenza viruses of different subtypes were isolated from fecal samples of ducks in their nesting areas in Siberia in summer from 1996 to 1999. Phylogenetic analysis of the NP genes of the isolates in Siberia and Japan on their flyway of migration to the south indicate that influenza viruses perpetuated in ducks nesting in Siberia should have contributed genes in the emergence of the H5N1 virus in Hong Kong. Inactivated vaccine prepared from an avirulent H5N4 virus isolated from a migratory duck in Japan showed enough potency to induce protective immunity against the pathogenic H5N1 virus in mice. To expand surveillance for influenza viruses in migratory and domestic ducks and geese, chickens, quail, and pigs of the world and be informed about what influenza viruses are dominant in the animal reservoirs, we have started the “Programme of Excellence in Influenza”. Influenza virus strains isolated from animal species in the surveillance should be thoroughly characterized, stored, and be provided for the use of diagnosis and vaccine preparation for the control of future pandemics.

Url:
DOI: 10.1016/S0531-5131(01)00665-3


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<div type="abstract" xml:lang="en">Abstract: Influenza viruses of different subtypes were isolated from fecal samples of ducks in their nesting areas in Siberia in summer from 1996 to 1999. Phylogenetic analysis of the NP genes of the isolates in Siberia and Japan on their flyway of migration to the south indicate that influenza viruses perpetuated in ducks nesting in Siberia should have contributed genes in the emergence of the H5N1 virus in Hong Kong. Inactivated vaccine prepared from an avirulent H5N4 virus isolated from a migratory duck in Japan showed enough potency to induce protective immunity against the pathogenic H5N1 virus in mice. To expand surveillance for influenza viruses in migratory and domestic ducks and geese, chickens, quail, and pigs of the world and be informed about what influenza viruses are dominant in the animal reservoirs, we have started the “Programme of Excellence in Influenza”. Influenza virus strains isolated from animal species in the surveillance should be thoroughly characterized, stored, and be provided for the use of diagnosis and vaccine preparation for the control of future pandemics.</div>
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